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Amino Acid Breakdown Notes

This is a sample of our (approximately) 4 page long Amino Acid Breakdown notes, which we sell as part of the Metabolic Pathways Notes collection, a First (82%) package written at Queen Mary, University Of London in 2013 that contains (approximately) 73 pages of notes across 33 different documents.

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Amino Acid Breakdown Revision

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Amino Acid Breakdown: Nitrogen - converted to urea and removed. Carbon skeletons - degrade to citric acid cycle components/precursors. Varied breakdown pathways:

• Glucogenic - breakdown to glucose precursors (pyruvate, succinyl CoA, oxaloacetate).

• Ketogenic - breakdown to ketone bodies precursors (acetyl CoA/acetoacetyl CoA). Pyruvate Formation

• Tryptophan  Alanine

• Glycine  Serine (both go into C1 unit pool)

• Cysteine

• Threonine Oxaloacetate Formation

• Aspartate (direct transamination)

• Asparagine
α-Ketoglutarate Formation

• Glutamine/Proline/Arginine/Histidine (5C residues)  Glutamate  α-Ketoglutarate Succinyl CoA Formation

• Methionine/Valine/Isoleucine Propionyl CoA  Methylmalonyl CoA Succinyl CoA

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