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Cholesterol Synthesis Notes

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Cholesterol Synthesis Revision

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Cholesterol: Has a crucial role in:

• Structure of membranes

• Precursor of steroid hormones

• Precursor to bile acids and vitamin D Sources of cholesterol

• Diet

• De novo synthesis

• Synthesised in extrahepatic tissues (outside liver) It is an essential molecule but not required in diet as all cells can synthesise it from simple precursors.

Ne Novo Cholesterol Synthesis: Occurs in cytosol. Activated carriers used: NADPH and ATP All carbon atoms provided by acetate (as acetyl CoA). It is a very energy intensive process. Requires 18 ATP. 18 Acetyl CoA + 18ATP + 16NADPH + 4O2Cholesterol + 9CO2 + 16NADP+ + 18ADP + 18Pi

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