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Fatty Acid Metabolism And Degradation Notes

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Fatty Acid Metabolism And Degradation Revision

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Utilisation of Fatty Acids as Fuel: 3 stages of processing:

1. TGs degraded to FAs and glycerol and transported to other tissues

2. FAs activated and transported into mitochondria

3. FAs broken down into 2C acetyl CoA units and fed into citric acid cycle

1. Breakdown of Triacylglycerides Lipases hydrolyse TAGs into FAs and monoacylglycerol. Bile salts solubilise TGs. MAG and FAs absorbed by mucosal cells in small intestine. Inside cells MAG and FAs condensed back into TGs. Intestinal cells assemble TGs into chylomicrons and transport to other tissues via blood.

2. Activation of fat stores At low levels of glucose, the body secretes epinephrine and glucagon. Hormones release second messenger cAMP, which activates PKA. PKA phosphorylates and activates lipase. Lipase hydrolyses stored TGs to release FAs. Mobilised FAs released into bloodstream and transported to where needed. Glycerol converted to glycolytic intermediates, fed into glycolysis or gluconeogenesis.

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