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Fatty Acid Synthesis Notes

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Ketone Bodies: In starvation or diabetes conditions acetyl CoA cannot enter citric acid cycle. Instead, acetyl CoA forms ketone bodies. 2 acetyl CoA + H2O  acetoacetate + 2 CoA + H+
2 molecules of acetyl CoA condense (addition of water and acetyl). Ketone bodies as a fuel source Liver is main source of ketone bodies, transported in blood to other tissues. Acetoacetate activated to acetoacetate CoA, then split into 2 acetyl CoA

Fatty Acid Synthesis: Acetyl CoA monomers come together to give C16 FA polymer. Takes place in cytosol, via citrate shuttle. Activated carriers used: Biotin, NADP+/NADPH, ACP (activated carrier protein), ATP Type of reactions involved: condensation, reduction, translocation, reduction 3 steps:

1. Formation of malonyl CoA (2C  3C) - irreversible committed step

2. Fatty acid synthase complex

3. Elongation reactions

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