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Ribonucleotide Reductase Notes

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Ribonucleotide Reductase Revision

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Ribonucleotide Reductase (RNR): Catalyses formation of deoxyribonucleotides (NDP  dNDP). 3 classes of enzyme, classified by metal ion and cofactor requirements. All perform similar reactions - all use free radical mechanism, all replace 2'OH with 2'-H. Class I Aerobic RNR Found in all eukaryotes and many prokaryotes Uses tyrosyl free radical and binuclear Fe(III) complex Class II Aerobic and anaerobic RNR Found only in prokaryotes Uses coenzyme B12

Class III Anaerobic RNR Found only in prokaryotes Uses iron-sulphur complex with Gly radical

Class I Enzymes: E. Coli RNR consists of dimer of dimers: 2 RI (α) subunits, 2 R2 (β) - form a α2β2 tetramer. Site of catalytic activity is at interface between α and β subunits.

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