This is a sample of our (approximately) 5 page long Receptors notes, which we sell as part of the Clinical Psychiatry Notes collection, a 1st package written at Bristol University in 2014 that contains (approximately) 47 pages of notes across 21 different documents.
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How do they work?
o Neuron transmit info within neuron via electrical impulse o Majority communication mediated by chemical signal (NTs) that affect electrical potentials or intracellular chemistry in 'receiving' neuron o Neurons supported by glia o Brain integrates all events & produces outputs
Molecules affecting function o NT production/metabolism/release L-Tryptophan/Phenelzine/damphetamine o Receptor function Mirtazapine o Transporter function Escilatopram o Ion channel function Pregabalin o Cellular chemistry Lithium o Nuclear function Hydrocortisone
What are receptors/Types?
o Protein that change configuration once molecules (ligands) bind o Produce change in
Working right now. On/Off
Cellular chemical signalling (METABOTROPIC)
Slower acting; Most psych drugs use o Number modulated (upregulation/downregulation) o Post/Pre-synaptic o Heteroreceptors= Associated w/ particular NT that modulates release of another NT
Function of receptor ligands o Agonist Agomelatine o Partial agonist Aripiprazole o Antagonist Haloperidol o Partial inverse agonist RO 15-4513
What are transporters?
o Proteins that use energy to move molecules across cell mebranes o Transport/re-uptake sites= Proteins that clear-up NT from synapse (serotonin; SSRI)
Enzyme modulation o Blocking enzymes reduce function= Increasing/Decreasing target substance o Competitive/Non-competitive o Reversible/Irreversible
How do molecules affect neurotransmission?
o Increase/Decrease amount NT in synapse e.g. Reboxetine o Modulate efficacy of NT e.g. Benzodiazepines o Affect receptor, blocking effect of NT/stimulating activity e.g. Aripiprazole
Effect number different sites. Advantage (Colizipine)/Disadvantage (Tricyclics)
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