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Receptors Notes

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This is an extract of our Receptors document, which we sell as part of our Clinical Psychiatry Notes collection written by the top tier of Bristol University students.

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? ? ? ? How do they work?
o Neuron transmit info within neuron via electrical impulse o Majority communication mediated by chemical signal (NTs) that affect electrical potentials or intracellular chemistry in 'receiving' neuron o Neurons supported by glia o Brain integrates all events & produces outputs
? ? ? ? Molecules affecting function o NT production/metabolism/release L-Tryptophan/Phenelzine/damphetamine o Receptor function Mirtazapine o Transporter function Escilatopram o Ion channel function Pregabalin o Cellular chemistry Lithium o Nuclear function Hydrocortisone
? ? ? ? What are receptors/Types?
o Protein that change configuration once molecules (ligands) bind o Produce change in
? Conductance (IONOTROPIC)
?? ? ?Working right now. On/Off
? Cellular chemical signalling (METABOTROPIC)
?? ? ?G-proteins/Tyrosine kinase
?? ? ?Slower acting; Most psych drugs use o Number modulated (upregulation/downregulation) o Post/Pre-synaptic o Heteroreceptors= Associated w/ particular NT that modulates release of another NT
? ? ? ? Function of receptor ligands o Agonist Agomelatine o Partial agonist Aripiprazole o Antagonist Haloperidol o Partial inverse agonist RO 15-4513
? ? ? ? What are transporters?
o Proteins that use energy to move molecules across cell mebranes o Transport/re-uptake sites= Proteins that clear-up NT from synapse (serotonin; SSRI)
? ? ? ? Enzyme modulation o Blocking enzymes reduce function= Increasing/Decreasing target substance o Competitive/Non-competitive o Reversible/Irreversible
? ? ? ? How do molecules affect neurotransmission?
o Increase/Decrease amount NT in synapse e.g. Reboxetine o Modulate efficacy of NT e.g. Benzodiazepines o Affect receptor, blocking effect of NT/stimulating activity e.g. Aripiprazole
? ? ? ? Dirty drugs?=
Effect number different sites. Advantage (Colizipine)/Disadvantage (Tricyclics)
? ? ? ? Ascending/Descending modulation

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