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Receptors Notes

This is a sample of our (approximately) 5 page long Receptors notes, which we sell as part of the Clinical Psychiatry Notes collection, a 1st package written at Bristol University in 2014 that contains (approximately) 47 pages of notes across 21 different documents.

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    How do they work?
o Neuron transmit info within neuron via electrical impulse o Majority communication mediated by chemical signal (NTs) that affect electrical potentials or intracellular chemistry in 'receiving' neuron o Neurons supported by glia o Brain integrates all events & produces outputs
    Molecules affecting function o NT production/metabolism/release L-Tryptophan/Phenelzine/damphetamine o Receptor function Mirtazapine o Transporter function Escilatopram o Ion channel function Pregabalin o Cellular chemistry Lithium o Nuclear function Hydrocortisone
    What are receptors/Types?
o Protein that change configuration once molecules (ligands) bind o Produce change in
 Conductance (IONOTROPIC)
  Working right now. On/Off
 Cellular chemical signalling (METABOTROPIC)
  G-proteins/Tyrosine kinase
  Slower acting; Most psych drugs use o Number modulated (upregulation/downregulation) o Post/Pre-synaptic o Heteroreceptors= Associated w/ particular NT that modulates release of another NT
    Function of receptor ligands o Agonist Agomelatine o Partial agonist Aripiprazole o Antagonist Haloperidol o Partial inverse agonist RO 15-4513
    What are transporters?
o Proteins that use energy to move molecules across cell mebranes o Transport/re-uptake sites= Proteins that clear-up NT from synapse (serotonin; SSRI)
    Enzyme modulation o Blocking enzymes reduce function= Increasing/Decreasing target substance o Competitive/Non-competitive o Reversible/Irreversible
    How do molecules affect neurotransmission?
o Increase/Decrease amount NT in synapse e.g. Reboxetine o Modulate efficacy of NT e.g. Benzodiazepines o Affect receptor, blocking effect of NT/stimulating activity e.g. Aripiprazole
    Dirty drugs?=
Effect number different sites. Advantage (Colizipine)/Disadvantage (Tricyclics)
    Ascending/Descending modulation

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