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Diabetes Basics Notes

This is a sample of our (approximately) 4 page long Diabetes Basics notes, which we sell as part of the Diabetes (clinical) Notes collection, a 1st package written at Bristol University in 2014 that contains (approximately) 11 pages of notes across 4 different documents.

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Diabetes Basics Revision

The following is a plain text extract of the PDF sample above, taken from our Diabetes (clinical) Notes. This text version has had its formatting removed so pay attention to its contents alone rather than its presentation. The version you download will have its original formatting intact and so will be much prettier to look at.

Diabetes Basics
Glucose o Ubiquitous fuel in biology
 Energy source for most organisms o Critical in production of proteins and fats o Body's key energy source in aerobic respiration o Oxidised to form CO2 and H2O= energy as ATP
Normal fasting blood glucose range=3.5-5.6mmol/L o Over 7= DIABETES o Between 5.6 and 6.9= IMPAIRED FASTING GLYCAEMIA o Patient with abnormal fasting glucose should repeat test or have an oral glucose tolerance test
Organs and tissues involved in maintaining glucose balance o PANCREAS
 Alpha cells
 Beta cells
Insulin o Meal-->Increased glucose o Glucose into B cells by glut-1 transporter o Glucose broken down by mitochondria to ATP o ATP has 2 effects

1. ATP shuts of K+
channel->Depolarisation-->Ca channel opens->Ca into cells-->Vesicles exocytosed
-->Insulin released

2. ATP stimulates transcription factors->Transcript more insulin-->More insulin release o When initially released= PROINSULIN (inactive)

Centre Delta cells

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