Development Of The Gi System (Embryology) Notes
This is a sample of our (approximately) 4 page long Development Of The Gi System (Embryology) notes, which we sell as part of the Gastrointestinal (GI) System Notes collection, a 1st (70-80%) package written at Bristol University in 2012 that contains (approximately) 57 pages of notes across 19 different documents.
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Development Of The Gi System (Embryology) Revision
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Lecture 6 Development of GI system (embryology)
Gastrulation o Week 3- Epiblast cells migrate through primitive streak to form Trilaminar disc
Displace hypoblasts= ENDODERM (CNS/PNS and epithelium of skin)
Lie in middle= MESODERM (Body connective tissues, GI connective tissue)
Remain in epiblast= ECTODERM (GI tract organs & epithelium of GI) Development of the GI system o Primitive gut tube
Stomadeum to proptadeum
Buds coming off= organs o Divisions of gut tube
Pharyngeal gut (part of foregut)
Foregut (COELIAC AXIS)
Hindgut (IMA) o Differentiation of gut
Dependent on interaction between endoderm "SHH genes" and mesoderm "HOX genes"
All different genes go to different places o Autonomic innervation
• Coeliac ganglion- Foregut structures
• SMA- Midgut structures
• IMA- Hindgut structures
• Vagus nerve- Foregut & midgut structures
• Pelvic splanchnic nerve- Hindgut structures o Mesenteries
• Structures support gut tube to body wall
• Derived from intraembryonic coelom (mesoderm)
• Includes o Megogastrium (greater omentum); mesoduodenum; mesentery proper; mesocolon
• Only related to foregut
• Derived from septum transversum o Falciform ligament- extending liver to ventral wall
Embryo: Unbilical vein
After birth: round ligament o Lesser omentum- extending stomach to liver
Portal triad: bile duct, hepatic artery, portal vein
Forms entrance to lesser sac: EPICLOIC FORAMEN OF WINSLOW o From which germ layer are the following parts of developing gut tube derived?
GI organs & GI mucosa= ENDODERM
Peritoneum, GI smooth muscle & dorsal mesentery= MESODERM
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