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Disorders Of Absorption Notes

Medicine Notes > Gastrointestinal (GI) System Notes

This is an extract of our Disorders Of Absorption document, which we sell as part of our Gastrointestinal (GI) System Notes collection written by the top tier of Bristol University students.

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Lecture 16 Disorders of absorption




Definitions o Malabsorption
? Failure of intestinal processes of digestion, transport, or both of nutrients across intestinal mucosa into systemic circulation o Malnutrition
? Outcome of Malabsorption
? Deficiency of nutrients such as energy, protein, vitamins &minerals causes measurable adverse effects on tissues, function or clinical outcome Mechanisms of absorption o Three types
? Luminal processing

* Carbs, fats and proteins hydrolysed and solubilised (pancreatic
& bilary action)
? Mucosal absorption

* Uptake of saccharides and peptides, lipids processed and packaged for cellular export
? Transfer into circulation

* Absorbed nutrients enter vascular or lymphatic circulation o Where can it go wrong?
? Luminal processing

* Surgery- inadequate mixing

* Pancreatic insufficiency

* Cholestasis- inadequate bile (blockage of duct- stones, cancer etc.)
? Mucosal absorption

* Brush border defects- coeliac

* Inflammation- Crohns
? Transfer into circulation

* Lymphatic disease- lymphangiectasis

* Enterocyte processing- abetalipoproteinaemia o Rare, autosomal recessive. Cannot transmit fats properly Signs and symptoms o General
? Varied presentation
? Multiple systems affected
? Depends upon underlying aetiology
? Can be asymptomatic o Presenting features
? Pain & bloating

* Inflammation or obstruction (Crohns)

* Bacterial fermentation & gaseous distension (norm gut flora change)
? Weight loss

* Often indicates small bowel pathology

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