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Hepatitis A E Viruses Notes

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This is an extract of our Hepatitis A E Viruses document, which we sell as part of our Gastrointestinal (GI) System Notes collection written by the top tier of Bristol University students.

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Lecture 12 Hepatitis A-E Viruses


Types of hepatitis


Hepatitis A o Clinical features
? Incubation period: Average 30 days
? Jaundice by age group: <6 yrs= <10%; 6-14 yrs= 40-50%; >14 yrs=70-80%
? Complications: Fulminant hepatitis; Cholestatic hepatitis; Relapsing hepatitis
? Chronic Sequelae= NONE o Virus transmission
? Close personal contact
? Contaminated food, water
? Blood exposure (rare) o Lab diagnosis
? Acute infection diagnosed by detection of HAV-IgM in serum EIA
? Past infection i.e. immunity determined by detection of HAV-IgG by EIA o Prevention- Immune Globulin
? Pre-exposure (travellers)
? Post-exposure (within 14 days)

* Routine (household and other intimate contacts)

* Selected situations (institutions, common source exposure) Hepatitis B o Clinical features
? Incubation period: Average 60-90 days
? Jaundice: <5yrs= <10%; >5yrs=30-50%
? Acute-case fatality rate= 0.5-1%
? Chronic infection: depends upon age of infection (older=less likely)
? Premature mortality from chronic liver disease= 15-25%
o Spectrum of chronic hep. B
? Chronic persistent hep. (asymptomatic)
? Chronic active hep (symptomatic exacerbations of hep.)
? Cirrhosis of liver


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