Hepatitis A E Viruses Notes
This is a sample of our (approximately) 3 page long Hepatitis A E Viruses notes, which we sell as part of the Gastrointestinal (GI) System Notes collection, a 1st (70-80%) package written at Bristol University in 2012 that contains (approximately) 57 pages of notes across 19 different documents.
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Hepatitis A E Viruses Revision
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Lecture 12 Hepatitis A-E Viruses
Types of hepatitis
Hepatitis A o Clinical features
Incubation period: Average 30 days
Jaundice by age group: <6 yrs= <10%; 6-14 yrs= 40-50%; >14 yrs=70-80%
Complications: Fulminant hepatitis; Cholestatic hepatitis; Relapsing hepatitis
Chronic Sequelae= NONE o Virus transmission
Close personal contact
Contaminated food, water
Blood exposure (rare) o Lab diagnosis
Acute infection diagnosed by detection of HAV-IgM in serum EIA
Past infection i.e. immunity determined by detection of HAV-IgG by EIA o Prevention- Immune Globulin
Post-exposure (within 14 days)
• Routine (household and other intimate contacts)
• Selected situations (institutions, common source exposure) Hepatitis B o Clinical features
Incubation period: Average 60-90 days
Jaundice: <5yrs= <10%; >5yrs=30-50%
Acute-case fatality rate= 0.5-1%
Chronic infection: depends upon age of infection (older=less likely)
Premature mortality from chronic liver disease= 15-25%
o Spectrum of chronic hep. B
Chronic persistent hep. (asymptomatic)
Chronic active hep (symptomatic exacerbations of hep.)
Cirrhosis of liver
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