Pharmacology Of Gi System Notes
This is a sample of our (approximately) 5 page long Pharmacology Of Gi System notes, which we sell as part of the Gastrointestinal (GI) System Notes collection, a 1st (70-80%) package written at Bristol University in 2012 that contains (approximately) 57 pages of notes across 19 different documents.
The original file is a 'Word (Docx)' whilst this sample is a 'PDF' representation of said file. This means that the formatting here may have errors. The original document you'll receive on purchase should have more polished formatting.
Pharmacology Of Gi System Revision
The following is a plain text extract of the PDF sample above, taken from our Gastrointestinal (GI) System Notes. This text version has had its formatting removed so pay attention to its contents alone rather than its presentation. The version you download will have its original formatting intact and so will be much prettier to look at.
Lecture 5 Pharmacology of GI system LECTURE 1
• Nausea and vomiting o
Act centrally to inhibit or prevent emesis Include antagonists of o D2 receptor (chemical trigger zone) o 5-HT receptor (chemical trigger zone) o H1-receptor (NTS) o AChM receptor (vomiting centre)
D2 Dopamine receptor antagonists o Phenothiazines- CHLORPROMAZINE & ACEPROMAZINE
• Good at preventing vomiting agents directly stimulating CTZ
• Sedative action= more useful for motion sickness
• Also antagonises H1 and AChM receptors (dirty)
• Hypotension, platelet dysfunction, ataxia
• Not recommended for pregnant, affects babies (+500mg) o METACLOPRAMIDE
• Blocks 5-HT3 receptors= large part of effect
• Peripheral actions- increased muscle tone in lower oesophageal sphincter (near stomach) to prevent vomiting
• As chlorpromazine, Diarrhoea 5-HT receptor antagonists o ONDANSETRON
Particularly useful in chemo/radiotherapy
Side effects: drowsiness & dizziness o NABILONE
Synthetic cannabinoid (not first choice- addiction)
Used in cytotoxic-induced vomiting
Side effect: drowsiness & dizziness 5-HT4 receptor agonists o CISAPRIDE
• Peripherally, increasing gastro-oesophageal sphincter contraction & GI motility
• Withdrawn= long QT-syndrome (death)
Side effects (high dosage)
• Diarrhoea, abdominal cramp
****************************End Of Sample*****************************
Buy the full version of these notes or essay plans and more in our Gastrointestinal (GI) System Notes.