Anticonvulsant Drugs Notes
This is a sample of our (approximately) 3 page long Anticonvulsant Drugs notes, which we sell as part of the Neurology Notes collection, a 70-80% package written at Bristol University in 2012 that contains (approximately) 117 pages of notes across 36 different documents.
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Anticonvulsant Drugs Revision
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Lecture 28 Anticonvulsant drugs
What is epilepsy?
Group of disorders all of which exhibit episodic seizures
Paroxysmal dysfunction of brain neurophysiology (as seen on EEG)
Accompanied by paroxysmal dysfunction of brain action (cognitive, behavioural, sensory, experiential)
Has a tendency to recur NB: Not to be confused with febrile convulsions (hyperthermia) in children o Major causes
Happen at young age
• Birth & perinatal injuries; congenital malformations
• Genetic (ion channels)
Can happen at any time
• Vascular insults; head trauma
• Severe metabolic disturbances
• Drug/alcohol abuse
Epilepsy from some kind of damage
• EPILEPTIC focus- can be observed for some epilepsies that result from physical injury o Some have seizure in one place=localised legion o Some have seizure that start in one place and moves=generalised (secondary) o Intermittent and precipitated by
Altered blood glucose and pH
Flashing lights and noise
No apparent cause Neurones exhibit PAROXYSMAL DEPOLARISING SHIFT (PAD) in epilepsy o Intracellular and extracellular events of PAD underlying the interictal epileptiform spoke detected by surface EEG o Theories of cause
• Presynaptic endings damaged and release lots of glutamate
• Nerves releasing normal amount of glutamate but post synaptic cell=hypersensitive
• Crumbly membrane and lets out + ions easily Types of seizure o Simple= no loss of consciousness o Complex= impairment of consciousness o Partial (localised) seizures
Most difficult to treat with drugs
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