Antidepressant Drugs Notes
This is a sample of our (approximately) 3 page long Antidepressant Drugs notes, which we sell as part of the Neurology Notes collection, a 70-80% package written at Bristol University in 2012 that contains (approximately) 117 pages of notes across 36 different documents.
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Antidepressant Drugs Revision
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Lecture 45 Antidepressant Drugs
Types of mood/affective disorder o Depression (monopolar)
• Emotional- Mood; Thought disorder
• Biological- Anhedonia (failure to feel reward)
• Cognitive- Difficulty decision making; Poor concentration
Drug treatments aim to improve mood and motivational impairments o Mania (monopolar) and bipolar disorder
• Sleep changes
• Excessive exuberance, enthusiasm and confidence, grandiosity
• Increased libido
• Behaviours inappropriate to circumstances
• Disorders of thought (psychosis)
Drugs aim to control excessive oscillations in mood Depression o Causes
• Monoamine theory (transmitters are dysfunctional)
• Functional deficit in 5-HT and/or NA (possibly DA)
• Neural apoptosis and neurogenesis
Immune response (sickness behaviour)
Environment (stress) o Treatments
• Enhance monoamine levels in CNS o Post-synaptic agonist (Buspirone- not antidepressant) o Pre-synaptic receptor antagonist (e.g. Mirtazipine) o MAO inhibitors (Moclobemide=reversible; phenylzine) o Re-uptake inhibitors (e.g. fluoxetine, venlafaxine) o Reuptake=most common target area
• Specific receptor agonists/antagonists
Cognitive behavioural therapy
• No use of pharmacological substances
• Mild to moderate; used in first instance
• Electroconvulsive shock therapy (lift to level drugs can be used; memory loss problems)
• Deep brain stimulation
• Vagal nerve stimulation o Classes of antidepressants
Typical (TCA and specific re-uptake inhibitors)
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