Someone recently bought our

students are currently browsing our notes.

X

Antidepressant Drugs Notes

Medicine Notes > Neurology Notes

This is an extract of our Antidepressant Drugs document, which we sell as part of our Neurology Notes collection written by the top tier of Bristol University students.

The following is a more accessble plain text extract of the PDF sample above, taken from our Neurology Notes. Due to the challenges of extracting text from PDFs, it will have odd formatting:

Lecture 45 Antidepressant Drugs

*

*

Types of mood/affective disorder o Depression (monopolar)
? Symptoms

* Emotional- Mood; Thought disorder

* Biological- Anhedonia (failure to feel reward)

* Cognitive- Difficulty decision making; Poor concentration
? Drug treatments aim to improve mood and motivational impairments o Mania (monopolar) and bipolar disorder
? Symptoms

* Sleep changes

* Excessive exuberance, enthusiasm and confidence, grandiosity

* Increased libido

* Behaviours inappropriate to circumstances

* Disorders of thought (psychosis)
? Drugs aim to control excessive oscillations in mood Depression o Causes
? Chemical imbalance

* Monoamine theory (transmitters are dysfunctional)

* Functional deficit in 5-HT and/or NA (possibly DA)
? Neurodegenerative

* Neural apoptosis and neurogenesis
? Immune response (sickness behaviour)
? Genes
? Environment (stress) o Treatments
? Pharmacological

* Enhance monoamine levels in CNS o Post-synaptic agonist (Buspirone- not antidepressant) o Pre-synaptic receptor antagonist (e.g. Mirtazipine) o MAO inhibitors (Moclobemide=reversible; phenylzine) o Re-uptake inhibitors (e.g. fluoxetine, venlafaxine) o Reuptake=most common target area

* Specific receptor agonists/antagonists
? Cognitive behavioural therapy

* No use of pharmacological substances

* Mild to moderate; used in first instance
? Neurological interventions

* Electroconvulsive shock therapy (lift to level drugs can be used; memory loss problems)

* Deep brain stimulation

* Vagal nerve stimulation o Classes of antidepressants
? Typical (TCA and specific re-uptake inhibitors)

* MAOI

Buy the full version of these notes or essay plans and more in our Neurology Notes.