This is a sample of our (approximately) 3 page long Plasticity notes, which we sell as part of the Neurology Notes collection, a 70-80% package written at Bristol University in 2012 that contains (approximately) 117 pages of notes across 36 different documents.
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Lecture 43 Plasticity
General o Need to be able to adapt our environment and store information
Learning & memory
Disease & addiction o Plasticity relates to the idea that the nervous system is modifiable o What can we change?
• 'All or nothing' so can't change size
• Could possibly change probability of AP being fired
• Can reduce amount of NT release & thus change EPSP Synaptic plasticity, development and memory o Cell death and synapse elimination/re-organisation
Establishing correct synaptic connections is essential to neuronal survival. Neurones lose in competition and fail to survive (keep important ones)
Neurons appear to have target synaptic activity (max. number of synapses) o Mechanisms of pathway formation
Large-scale reduction in neurons and synapses o Development of brain function
Balance between genesis and elimination of cells and synapses o Apoptosis: programmed cells death o Start off with more neurons than need, but during development, lose these Activity-dependent synaptic rearrangement o Synaptic rearrangement
Change from one pattern to another
Consequence of neural activity/synaptic transmission before and after birth
• A & B both have some amount of post-synaptic connections (3)
• B is driven more & has stronger connections & is more in tune with target cell. Makes more connections & keeps other connections (5) o Synaptic segregation
Refinement of synaptic connections
Segregation of retinal outputs
• Retinal waves (in utero)- activity of two eyes not correlated
segregation in LGN
• Process of synaptic stability (Hebbian modifications)
• Plasticity at Hebb synapses
• "Winner takes all" o Hebbian synaptic modification
Hebb synapse=strength changes when pre/postsynaptic neurons act together
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