Someone recently bought our

students are currently browsing our notes.

X

Nephrotic Syndrome Notes

Medicine Notes > Renal System Notes

This is an extract of our Nephrotic Syndrome document, which we sell as part of our Renal System Notes collection written by the top tier of Bristol University students.

The following is a more accessble plain text extract of the PDF sample above, taken from our Renal System Notes. Due to the challenges of extracting text from PDFs, it will have odd formatting:

Lecture 13 Nephrotic syndrome

*

*

*

General o Course of disease
? Heavy proteinuria
? Hypoalbuminaemia (Hyperlipidaemia)
? Oedema

* Leak fluid into 'third space' o Symptoms
? Oedema
? Hypoalbuminaemia
? Proteinuria
? Hyperlipidaemia o Different from nephritic syndrome, in which you are more likely to have
? High BP
? Acute renal impairment
? Haematuria
? Less oedema Pathophysiology of nephrotic syndrome o Normal
? Three layers of glomerulus from blood layer to inner space

* Endothelium (fenestrated)

* Glomerular BM

* Podocytes
? 180 litres/day of water and small molecules pass through glomerulus
? Almost no protein o Nephrotic syndrome
? Simplification of podocyte architecture
? Podocyte effacement (shortening or thinning of tissue)
? Protein (such as ALBUMIN) is able to pass through glomerular barrier

Classification of nephrotic syndrome o CONGENITAL
? Generalo

*

*

*

*

*

*
Genes

*

*

Rare, inherited conditions Proteinuria in utero or in early infancy Breakdown in glomerular filtration barrier- at podocyte level Usually rapid onset of ESRF No response to steroids or Cytotoxics Transplantation

NPHS1- nephrin NPHS2- podocin ACQUIRED (e.g. Primary glomerulopathy)
? Minimal change nephrotic syndrome

* Signs and symptoms o Don't see any difference in microscopy o Proteinuria, oedema, Hypoalbuminaemia o Risk of IV depletion, infection etc.

Buy the full version of these notes or essay plans and more in our Renal System Notes.