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Microbiology Of Lower Respiratory Tract Infections Notes

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Lecture 11 Microbiology of Lower Respiratory Tract Infections

Definition of LRTI o Any infection of respiratory tract from vocal cords downwards o Includes bronchi, bronchioles, alveoli, parenchyma, pleura & pleural cavities Normal flora of LRT o Normal LRT is bacteriologically sterile o Inhaled particles including microorganisms are trapped by mucus & moved to URT by epithelial cilia Abnormal flora of LRT o Paralysis of cilia o Excessive volume &/or viscosity of mucus o Paralysis, ventilation, failure to protect LRT o Failure to cough up debris from larger airways o Loss of swallowing reflex o "Colonisers" of LRT often from URT (such as Haemophilus influenza and Streptococcus pneumoniae) o Antibiotic therapy WILL affect URT colonisation Types of LRTI o Acute cough (

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