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Metabolic Intergration Notes

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METABOLIC INTERGRATION Substrate utilisation... Fatty acids
-Heart
-Skeletal muscle (especially type 1-highly aerobic)
-Liver
-Renal cortex Glucose
-Brain
-Red blood cells (no mitochondria)
-Renal medulla (poor circulation-hypoxic)
-Skeletal muscle (especially type 2 fibres) Amino acids
-Liver (all exept leucine, isolecuine, valine)
-Gut - glutamine, glutamate, aspartate
-Renal cortex- Glutamine
-Muscle- Leucine, isoleucine, valine Inter-organ relationships... Muscle-liver cycle CORI CYCLE: Lactate is produced during anaerobic respiration and is transported into the liver where it is converted into glucose and allows further oxidiation to continue
-alanine and glutamine are released from skeletal muscle during amino acid metabolism. These are gluconeogenic precursors and are transported to the liver where they are converted into glucose b) Fatty acid metabolism
-Dietary fat absorbed from enterocytes are converted into chylomicrons which are transported as triglycerides to the adipose tissue. Lipoprotein lipase breaks down the Triglyceride into fatty acids which is then stored as triglyceride in adipose tissue

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