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Genes In Population 5b Notes

Medicine Notes > Biochemistry Notes

This is an extract of our Genes In Population 5b document, which we sell as part of our Biochemistry Notes collection written by the top tier of Oxford students.

The following is a more accessble plain text extract of the PDF sample above, taken from our Biochemistry Notes. Due to the challenges of extracting text from PDFs, it will have odd formatting:

Genes in population Hardy-Weinberg principle: relative proportions of different gentoypes and phenotypes remain constant from one generation to another
-The assumption is that there are only 2 alleles for a particular gene in the population
-The gene pool= total alleles in the population (2 x population number)
-p= probability of a dominant allele, q= probability of a recessive allele so p+q=1
-p2 = probability of Homozygous for the dominant Allele
-q2 = probability of Homozygous for the recessive allele
-2pq= probability for being heterozygous
- p2 + 2pq + q2 = 1
-Use: allows us to predict the incidence of diseased individuals and unaffected carriers is p and q are known
-In order to calculate frequency of carriers you must do 2 x p x q not just p x q

-This theory is true for the ideal population
-Large
-Random mating -selection of a partner regardless of the partner's genotype
-no new mutations
-no selection for or against any particular genotype
-This is seen for neutral genes such as blood groups, enzyme variants

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