This is an extract of our Parathyroid Gland And Calcium Metabolism document, which we sell as part of our Endocrinology Notes collection written by the top tier of University Of Leicester students.
The following is a more accessble plain text extract of the PDF sample above, taken from our Endocrinology Notes. Due to the challenges of extracting text from PDFs, it will have odd formatting:
Parathyroid Gland and Calcium Metabolism Parathyroid gland Located on the posterior aspect of the thyroid. Number of glands can range between 4 and 150 in adults (usually 4-6). Produces parathyroid hormone. Parathyroid hormone
- Made as a pro-hormone and cleaved twice (in liver and kidney)
- Has no serum binding protein
- Half life is 4 minutes (short acting) Actions
- Raises serum calcium levels
- Changes in calcium concentration stimulate PTH release
- Acts on osteoblasts in bone = release of Ca2+ and PO4- Acts on tubular cells in kidney = increased absorption of Ca2+ and decreased absorption (increased excretion) of PO4- Stimulates absorption of bone and release of calcium into extracellular fluid Also stimulates conversion of vitamin D to its active form and increases calcium uptake from the intestine = increased synthesis of active vit D Skin UV Light
Pro Vit Liver 25, D3
Kidney (+) Low PO4
(+) Low PO4+
Calcitrol (1,25 Vit D) Intestine - increase Ca + PO4 absorption stores
Bone - mobilize Ca
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