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Pharmacology Of Psychiatric Drugs Notes

This is a sample of our (approximately) 7 page long Pharmacology Of Psychiatric Drugs notes, which we sell as part of the Psychiatry Notes collection, a MBChB (hons) (1st) package written at University Of Leicester in 2014 that contains (approximately) 43 pages of notes across 14 different documents.

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Psychiatric Drugs Administration

Mostly oral (so undergo 1st pass metabolism) IV/IM used in emergencies or in those who can't maintain on oral dose


Mostly lipid soluble so can cross the BBB Therefore all excreted in breast milk


Mostly by CYP450 hepatic enzymes


Mainly renal NB - Lithium is not metabolized, just renally excreted - risk of toxicity with renal disease

Mechanism of action
- Affect neurotransmitters such as

Excitatory neurotransmitters (dopamine, NA, 5-HT, glutamine)

Inhibitory neurotransmitters (GABA, glycine)

Drugs act to modulate action potentials by affecting reuptake, breakdown and receptors of these neurotransmitters

Antidepressants 1

Selective Serotonin Reuptake Inhibitors (SSRI) Fluoxetine, citalopram, sertraline Specific inhibition of 5-HT reuptake FIRST LINE for moderate to severe depression Also used for anxiety disorders (especially OCD)
- 2-4 weeks before they begin to have an effect
- Safe if taken alone in overdose
- Side effects include o Nausea, vomiting, diarrhea o Agitation, insomnia o Anorgasmia o Increase suicide risk in those

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