Medicine Notes > University Of Leicester Medicine Notes > Psychiatry Notes

Pharmacology Of Psychiatric Drugs Notes

This is a sample of our (approximately) 7 page long Pharmacology Of Psychiatric Drugs notes, which we sell as part of the Psychiatry Notes collection, a MBChB (hons) (1st) package written at University Of Leicester in 2014 that contains (approximately) 43 pages of notes across 14 different documents.

Learn more about our Psychiatry Notes

The original file is a 'Word (Docx)' whilst this sample is a 'PDF' representation of said file. This means that the formatting here may have errors. The original document you'll receive on purchase should have more polished formatting.

Pharmacology Of Psychiatric Drugs Revision

The following is a plain text extract of the PDF sample above, taken from our Psychiatry Notes. This text version has had its formatting removed so pay attention to its contents alone rather than its presentation. The version you download will have its original formatting intact and so will be much prettier to look at.

Psychiatric Drugs Administration

Mostly oral (so undergo 1st pass metabolism) IV/IM used in emergencies or in those who can't maintain on oral dose


Mostly lipid soluble so can cross the BBB Therefore all excreted in breast milk


Mostly by CYP450 hepatic enzymes


Mainly renal NB - Lithium is not metabolized, just renally excreted - risk of toxicity with renal disease

Mechanism of action
- Affect neurotransmitters such as

Excitatory neurotransmitters (dopamine, NA, 5-HT, glutamine)

Inhibitory neurotransmitters (GABA, glycine)

Drugs act to modulate action potentials by affecting reuptake, breakdown and receptors of these neurotransmitters

Antidepressants 1

Selective Serotonin Reuptake Inhibitors (SSRI) Fluoxetine, citalopram, sertraline Specific inhibition of 5-HT reuptake FIRST LINE for moderate to severe depression Also used for anxiety disorders (especially OCD)
- 2-4 weeks before they begin to have an effect
- Safe if taken alone in overdose
- Side effects include o Nausea, vomiting, diarrhea o Agitation, insomnia o Anorgasmia o Increase suicide risk in those <18yrs

May cause 'serotonin syndrome' (body response to too much serotonin)
- Tremor
- Hypothermia
- Cardiovascular collapse

Serotonin Noradrenaline Reuptake Inhibitors (SSNRIs)

Venlafaxine ADRs - Nausea/vomiting, diarrhea, dry mouth, hyponatraemia Short T1/2 (withdrawal syndrome)

Tricyclic Antidepressants (TCAs)

Amitriptyline, imipramine, Lower doses = neuropathic clomipramine pain Block reuptake of serotonin and NA Higher doses =
Also act on
- H1 receptors = sedation effects
- A1 receptors
- Muscarinic receptors = anticholinergic effects e.g dry mouth, blurred vision, constipation, urinary retention Onset of action = 4 weeks Other side effects
- Initially o Sedation, confusion and motor impairment o Usually wears off after 2 weeks
- Long term o Drowsiness, poor concentration, postural hypotension
- Overdose o Initial euphoria o Delerium, convulsions, respiratory depression, coma o Severe anticholinergic effects o NA block Cardiac toxicity o Prolonged QT syndrome, ventricular arrhythmias Potentiates the effects of alcohol and anaesthetics (respiratory depression) Interferes with anti-hypertensives Slow elimination especially in elderly


****************************End Of Sample*****************************

Buy the full version of these notes or essay plans and more in our Psychiatry Notes.