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Pharmacology Of Psychiatric Drugs Notes

This is a sample of our (approximately) 7 page long Pharmacology Of Psychiatric Drugs notes, which we sell as part of the Psychiatry Notes collection, a MBChB (hons) (1st) package written at University Of Leicester in 2014 that contains (approximately) 43 pages of notes across 14 different documents.

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Psychiatric Drugs Administration
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Mostly oral (so undergo 1st pass metabolism) IV/IM used in emergencies or in those who can't maintain on oral dose

Distribution
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Mostly lipid soluble so can cross the BBB Therefore all excreted in breast milk

Metabolism
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Mostly by CYP450 hepatic enzymes

Excretion
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Mainly renal NB - Lithium is not metabolized, just renally excreted - risk of toxicity with renal disease

Mechanism of action
- Affect neurotransmitters such as

Excitatory neurotransmitters (dopamine, NA, 5-HT, glutamine)

Inhibitory neurotransmitters (GABA, glycine)

Drugs act to modulate action potentials by affecting reuptake, breakdown and receptors of these neurotransmitters

Antidepressants 1

Selective Serotonin Reuptake Inhibitors (SSRI) Fluoxetine, citalopram, sertraline Specific inhibition of 5-HT reuptake FIRST LINE for moderate to severe depression Also used for anxiety disorders (especially OCD)
- 2-4 weeks before they begin to have an effect
- Safe if taken alone in overdose
- Side effects include o Nausea, vomiting, diarrhea o Agitation, insomnia o Anorgasmia o Increase suicide risk in those

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