Medicine Notes > University Of Oxford Medicine Notes > Neuroscience Notes

Animal Models Of Brain Disorder (Short) Notes

This is a sample of our (approximately) 7 page long Animal Models Of Brain Disorder (Short) notes, which we sell as part of the Neuroscience Notes collection, a First package written at University Of Oxford in 2013 that contains (approximately) 96 pages of notes across 7 different documents.

Learn more about our Neuroscience Notes

The original file is a 'Word (Docx)' whilst this sample is a 'PDF' representation of said file. This means that the formatting here may have errors. The original document you'll receive on purchase should have more polished formatting.

Animal Models Of Brain Disorder (Short) Revision

The following is a plain text extract of the PDF sample above, taken from our Neuroscience Notes. This text version has had its formatting removed so pay attention to its contents alone rather than its presentation. The version you download will have its original formatting intact and so will be much prettier to look at.

Animal models of brain disorder Why do we need animal models of brain disorder?
What brain disorders can we model?
How do we test the validity of a model?
How do we construct a model?
How do we make genetic models?
Mouse vs. man Charles Darwin, The Descent of Man - "…the difference in mind between man and the higher animals, great as it is, certainly is one of degree and not of kind…" Why do we need animal models?

High cost and time investment of clinical studies and trials Technical challenge of measuring neural function in patients Need to understand better the neurobiological basis of symptoms Investigate the role of genes and signaling pathways in disease pathophysiology Investigate the role of gene/environment interactions in disease pathophysiology Make better and more effective treatments

Examples of brain disorders that we think that we can model PSYCHIATRIC DISORDERS: Depression Anxiety Schizophrenia Compulsive drug use NEURODEGENERATIVE DISORDERS: Alzheimer's Parkinson's Huntington's OTHER NEUROLOGICAL DISORDERS: Epilepsy Cerebral ischemia (stroke) Testing the validity of a model

1. construct validity - How good is the theoretical rationale? (gene mutation, neuronal lesion, developmental origin)

2. face validity - how good are the similarities with the human condition?
(behavioural symptoms, neuropathology)

3. predictive validity - how accurate are predictions made from the model (effects of treatments, disease progression) Constructing an animal model

Pharmacological manipulation o Neuronal lesion o Transmitter modulation Environmental manipulation o Behavioural conditioning o Behavioural stressors o Adverse early life events Genetic manipulation o Gene KO o Gene knock in o Selective breeding o Chemical mutagenesis

Some animal models of depression

Environmental stress o Chronic mild stress o Social defeat Maternal separation o Rodents o Primates Selective breeding o "Rouen depressed mice" olfactory bulbectomy tryptophan-free diet stimulant-induced hyperactivity (mania)

****************************End Of Sample*****************************

Buy the full version of these notes or essay plans and more in our Neuroscience Notes.