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Brain Killers Notes

Pharmacology Notes > BIOL10832 Excitable Cells Notes

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Excitable Cells - Lecture 18 (19/04/2018)
Brain Killers
These are degenerative diseases that include:








Stroke.
Brain injury.
Multiple sclerosis.
Parkinson's disease.
Motor Neurone disease.
Alzheimer disease.
Brain tumours.
Epilepsy.
CJD.

The things that all these diseases have in common is that they cause neuronal damage or death and can be acute or chronic.
In many cases the causes are not understood and treatments are still being developed.
So, additional understanding and research is required.


Stroke

Stroke is a result of reduced blood flow and oxygen to the brain.
It is the 3rd greatest killer in the western world.

Causes of Stroke:





Brain artery blocks.
Brain artery bleeds.
Poor general circulation.
Heart failure.
Drowning.
Low oxygen at birth.

There are limited treatments available for stroke.

The brain accounts for:




2-3% of body weight.
15% of cardiac output.
20% of all O2.
25% of all glucose.

The brain is critically dependent on a constant blood supply. 

The brain has a very efficient transport system, particularly for the transport of oxygen and nutrients.

Because of the isolated nature of the brain from the rest of the body, certain substances essential for normal brain function need to gain access and waste/harmful products need to be removed.

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