Someone recently bought our

students are currently browsing our notes.

X

Adrenergic Receptors Notes

Medicine Notes > Physiology and Pharmacology Notes

This is an extract of our Adrenergic Receptors document, which we sell as part of our Physiology and Pharmacology Notes collection written by the top tier of Oxford students.

The following is a more accessble plain text extract of the PDF sample above, taken from our Physiology and Pharmacology Notes. Due to the challenges of extracting text from PDFs, it will have odd formatting:

Adrenergic receptors
-injection of adrenaline has two kinds of effects
-vasoconstriction in certain vascular beds: rise in arterial pressure
-vasodilation in other tissues
-If animal is injected with ergot, adrenaline caused a fall in arterial pressure
-This showed there were two different receptors and are classified according to the potency of catecholamines. A: noradrenaline > adrenaline > isoprenaline B: isoprenaline > adrenaline > noradrenaline

Key location and effects of

adrenoreceptors

Receptor stimulation: AGONIST: An agent binding to a receptor and stimulates a response With sympathetic a & b receptors : agonist may be referred to as
-sympathetic agonist
-sympathomimetic agent/agonist
-adrenergic receptor
-adrenoreceptor agonist
-the agonist can act directly or indirectly (or a combination of both)
-Direct action on receptor
-noradrenaline/adrenaline/isoprenaline
-Indirect action to release noradrenaline
-tyramine, ephedrine, amphetamine (displaces NA from the storage vesicles) Noradrenline and adrenaline
-these are non selective adrenoreceptor agonists - activates alpha and beta receptors. There is also a danger of ventricular fibrillation
-noradrenaline is more potent that adrenaline in activating alpha1, beta1 receptors
-adrenaline is more potent than noradrenaline in activating a2 and b2 receptorss
-its use is limited to severe acute conditions Anaphylactic shock: reverses bronchospasm Heart stimulation (negative as it leads the ventricular dysrhythmias) Acute cardiac failure: heart stimulation, vasoconstriction (negative as it increases peripheral resistance, this increases the workload of the heart Also applied with local anaesthetics: the vasoconstriction mediated by the adrenaline increases the time period and increases the concentration of the local anaesthetic in a certain place.

Buy the full version of these notes or essay plans and more in our Physiology and Pharmacology Notes.

More Physiology And Pharmacology Samples