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Renal Acid Base Regulation Notes

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This is an extract of our Renal Acid Base Regulation document, which we sell as part of our Physiology and Pharmacology Notes collection written by the top tier of Oxford students.

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Renal acid base regulation pH= -log10 (H+), normal arterial pH is 7.4, (H+)= 40nm Very important to maintain constant pH in both the intracellular and extracellular compartments of the body , otherwise denature proteins, prevent enzymatic reactions from taking place There are three lines of defence against acidosis/alkalosis
-Buffers, ventilator mechanisms, renal mechanisms Buffer: The primary buffer in the body is HC03- and its main function is to minimise the magnitidue of Ph changes via the reversible reaction a) Ventilator mechanisms
-the pH resulting from solution of C02 in the blood and consequent dissociation of carbonic acid is given by Henderson-Hasselbalch equation H2C03 ? H+ + HC03- normal HC03- concentration extracellular is 24nm, Pc02 is 40Kpa, so substituting the values gives pH = 7.4

-Ratio of bicarbonate : Pc02 x 0.03 remains equal to 20, the pH remains at

7.4. The bicarbonate concentration is determined by the kidney and the pC02 by the lung
-If excess HC03-, base excess, alkalinity, base deficit leads to acidity

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