Acute Coronary Syndrome Notes
This is a sample of our (approximately) 4 page long Acute Coronary Syndrome notes, which we sell as part of the Cardiology Notes collection, a MBChB (hons) (1st) package written at University Of Leicester in 2014 that contains (approximately) 27 pages of notes across 8 different documents.
The original file is a 'Word (Docx)' whilst this sample is a 'PDF' representation of said file. This means that the formatting here may have errors. The original document you'll receive on purchase should have more polished formatting.
Acute Coronary Syndrome Revision
The following is a plain text extract of the PDF sample above, taken from our Cardiology Notes. This text version has had its formatting removed so pay attention to its contents alone rather than its presentation. The version you download will have its original formatting intact and so will be much prettier to look at.
Acute Coronary Syndrome ACS = term covers
- Unstable angina
Similar underlying pathology of atherosclerosis, plaque rupture and thrombosis
Risk factors Non-modifiable o Smoking o Hypertension o Diabetes o Hyperlipidaemia o Obesity o Sedentary lifestyle
Modifiable o Age o Gender o Family history (1st degree relative < 55yrs)
- Myocardial ischaemia occurs when there is an imbalance between the supply of O2 + myocardial demand for it
- Coronary blood flow to a particular region of the heart may be reduced by o Mechanical obstruction e.g atheroma, thrombosis, spasm, embolus o Decreased flow of oxygenated blood e.g anaemia, hypotension
- Increased myocardial demand for O2 may be caused by o Increased cardiac output e.g thyrotoxicosis o Myocardial hypertrophy
- Myocardial ischaemia most commonly occurs from obstructive CAD in the form of coronary atherosclerosis Process of atherosclerosis Endothelial injury Result of mechanical stresses e.g hypertension Biochemical abnormalities e.g raised LDL, DM Immunological factos e.g free radicles from smoking Genetic alteration Accumulation of lipids and macrophages leads to foam cells Form the fatty streak Cytokine release causes further accumulation of macrophages
+ SMC migration and proliferation (A 50%
reduction in luminal diameter causeses sig. haemodynamic stenosis, therefore any increased in myocardial
= Plaque Plaque becomes unstable Rupture Thrombosis
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Buy the full version of these notes or essay plans and more in our Cardiology Notes.