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Gord Ulcers Notes

Medicine Notes > Gastrointestinal Disease Notes

This is an extract of our Gord Ulcers document, which we sell as part of our Gastrointestinal Disease Notes collection written by the top tier of University Of Leicester students.

The following is a more accessble plain text extract of the PDF sample above, taken from our Gastrointestinal Disease Notes. Due to the challenges of extracting text from PDFs, it will have odd formatting:

Gastro-oesophageal reflux disease (GORD)
= Dysfunction of lower oesophageal sphincter predisposes to gastrooesophageal reflux of acid Pathophysiology LOS = physiological sphincter formed by
- Angle of entry to stomach
- Mucosal folds of stomach (rugae)
- Diaphragm Reflux may be caused by
- Transient LOS relaxations
- Low resting tone that fails to increase on lying or with increased intrabdominal pressure
- Hiatus hernia
- Delayed gastric emptying Risk factors for reflux
- Smoking
- Alcohol
- Hiatus hernia
- Large meals
- Systemic sclerosis
- Drugs (antimuscarinics, nitrates, calcium channel blockers)
- Obesity
- Pregnancy Clinical features
- Heartburn o Burning retrosternal discomfort
- Belching
- Acid brash
- Nocturnal asthma Investigations
- Clinical diagnosis in most with no need for investigations (<45yrs) for those with no alarm symptoms o Dysphagia, weight loss, odonyphagia, anorexia, haematemesis, meleana
- Otherwise o Endoscopy, barium swallow, 24hr oesophageal monometry and pH monitoring Management
- Lifestyle o Meal times, lying flat, smoking, drinking etc
- Drugs o Antacids o H2 receptor antagonists o PPI o Prokinetics (metoclopramide)

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