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Breast Cancer Notes

Medicine Notes > Oncology Notes

This is an extract of our Breast Cancer document, which we sell as part of our Oncology Notes collection written by the top tier of University Of Leicester students.

The following is a more accessble plain text extract of the PDF sample above, taken from our Oncology Notes. Due to the challenges of extracting text from PDFs, it will have odd formatting:

Breast Cancer EpidemiologyCommonest female cancer

AetiologyRisk factors o Age
? Very rare <30years
? Increased risk up to age of menopause
? Rate of increased risk slows after menopause o Age of menarche and menopause
? Early menarche and late menopause = increased risk o Pregnancies
? Nulliparity
? Late first pregnancy o Family history
? BRCA 1+2 o Exogenous oestrogens
? COCP
? HRT o Diet
? Increased fat intake
? Obesity
? Alcohol o Previous atypical hyperplasia o Radiation

Genetics5-10% of cases are due to inherited mutated BRCA 1/2
Cause younger age of onset More male cases Associated with ovarian and prostate cancers Can be inherited through the father's side - always ask about paternal family history

Pathology-More common in upper outer quadrant Ductal carcinoma in situ o Atypical proliferation of ductal epithelium o Doesn't invade basement membrane o Usually impalpable o Seen as microcalcification on mammography o < 50% progress to invasive cancer Lobular carcinoma in situ o Pre-invasive lesion o Rare o Difficult to diagnose Invasive ductal carcinoma o Commonest type

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