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Adrenal Disease Notes

Medicine Notes > Endocrinology Notes

This is an extract of our Adrenal Disease document, which we sell as part of our Endocrinology Notes collection written by the top tier of University Of Leicester students.

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Adrenal Disease

Mineralocorticoids e.g aldosterone
- Predominant effect is on extracellular balance of Na + K in distal tubule of kidney
- Secretion under control (mainly) of RAS Glucocorticoids e.g cortisol (cross over with mineralocorticoids)
- Stimulate Inhibit o Gluconeogenesis
- Protein synthesis o Glycogen
- Response to infection deposition o Proteolysis o Fat deposition Arcadian rhythm, stress Axis Hypothalamus hormone)


Anterior Pituitary Adrenal Gland

CRH (corticotrophin releasing Portal system

ACTH Cortisol + weak androgens

Cushing's Syndrome
= Clinical state of free increase in circulating glucocorticoid (cortisol) Aetiology 1) ACTH-dependent causes (increased ACTH) a. Cushing's Disease = pituitary adenoma secreting ACTH i. Adrenal hyperplasia b. Ectopic ACTH production = especially small cell lung ca +
carcinoid tumours c. Rare ectopic CRH production from thyroid/prostate carcinoma or iatrogenic due to ACTH administration

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