This is an extract of our Adrenal Disease document, which we sell as part of our Endocrinology Notes collection written by the top tier of University Of Leicester students.
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Mineralocorticoids e.g aldosterone
- Predominant effect is on extracellular balance of Na + K in distal tubule of kidney
- Secretion under control (mainly) of RAS Glucocorticoids e.g cortisol (cross over with mineralocorticoids)
- Stimulate Inhibit o Gluconeogenesis
- Protein synthesis o Glycogen
- Response to infection deposition o Proteolysis o Fat deposition Arcadian rhythm, stress Axis Hypothalamus hormone)
Anterior Pituitary Adrenal Gland
CRH (corticotrophin releasing Portal system
ACTH Cortisol + weak androgens
= Clinical state of free increase in circulating glucocorticoid (cortisol) Aetiology 1) ACTH-dependent causes (increased ACTH) a. Cushing's Disease = pituitary adenoma secreting ACTH i. Adrenal hyperplasia b. Ectopic ACTH production = especially small cell lung ca +
carcinoid tumours c. Rare ectopic CRH production from thyroid/prostate carcinoma or iatrogenic due to ACTH administration
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