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Receptors Notes

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This is an extract of our Receptors document, which we sell as part of our Clinical Psychiatry Notes collection written by the top tier of Bristol University students.

The following is a more accessble plain text extract of the PDF sample above, taken from our Clinical Psychiatry Notes. Due to the challenges of extracting text from PDFs, it will have odd formatting:

Receptors
? ? ? ? How do they work?
o Neuron transmit info within neuron via electrical impulse o Majority communication mediated by chemical signal (NTs) that affect electrical potentials or intracellular chemistry in 'receiving' neuron o Neurons supported by glia o Brain integrates all events & produces outputs
? ? ? ? Molecules affecting function o NT production/metabolism/release L-Tryptophan/Phenelzine/damphetamine o Receptor function Mirtazapine o Transporter function Escilatopram o Ion channel function Pregabalin o Cellular chemistry Lithium o Nuclear function Hydrocortisone
? ? ? ? What are receptors/Types?
o Protein that change configuration once molecules (ligands) bind o Produce change in
? Conductance (IONOTROPIC)
?? ? ?Working right now. On/Off
? Cellular chemical signalling (METABOTROPIC)
?? ? ?G-proteins/Tyrosine kinase
?? ? ?Slower acting; Most psych drugs use o Number modulated (upregulation/downregulation) o Post/Pre-synaptic o Heteroreceptors= Associated w/ particular NT that modulates release of another NT
? ? ? ? Function of receptor ligands o Agonist Agomelatine o Partial agonist Aripiprazole o Antagonist Haloperidol o Partial inverse agonist RO 15-4513
? ? ? ? What are transporters?
o Proteins that use energy to move molecules across cell mebranes o Transport/re-uptake sites= Proteins that clear-up NT from synapse (serotonin; SSRI)
? ? ? ? Enzyme modulation o Blocking enzymes reduce function= Increasing/Decreasing target substance o Competitive/Non-competitive o Reversible/Irreversible
? ? ? ? How do molecules affect neurotransmission?
o Increase/Decrease amount NT in synapse e.g. Reboxetine o Modulate efficacy of NT e.g. Benzodiazepines o Affect receptor, blocking effect of NT/stimulating activity e.g. Aripiprazole
? ? ? ? Dirty drugs?=
Effect number different sites. Advantage (Colizipine)/Disadvantage (Tricyclics)
? ? ? ? Ascending/Descending modulation

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