Cancer Of The Upper Gi Tract Notes
This is a sample of our (approximately) 3 page long Cancer Of The Upper Gi Tract notes, which we sell as part of the Gastrointestinal (GI) System Notes collection, a 1st (70-80%) package written at Bristol University in 2012 that contains (approximately) 57 pages of notes across 19 different documents.
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Cancer Of The Upper Gi Tract Revision
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Lecture 10 Cancer of the upper GI tract
Anatomy of oesophagus o 25cm in posterior mediastinum o Cricopharyngeus to stomach o Muscular wall, no serosa o Aortic branches o Vagus innervation o Squamous lining, columnar at OGJ Cancer of the oesophagus (two types) o Squamous cell cancer
In western world, incidence decreasing (still high in east)
• Cigarettes & alcohol (highest risk factors, combined= x20 risk)
• Diet (low in fruit & veg, nitrosamines, vit. A & C, riboflavin &
• Plummer- Vinson syndrome (iron d. anaemia & dysplasia) RARE
• Tylosis (thickening of skin on palms and soles) RARE
• Eating/drinking scolding hot things increases risk o Adenocarcinoma
Increasing incidence in western world
Majority of oesophageal cancer seen (80-90%)
• Barrett's oesophagus (caused by GORD0
• BMI (overweight=increased risk)
• Smoking and alcohol
• H. pylori= protective against adenocarcinoma Barrett's oesophagus o UK definition
" Oesophagus in which portion of normal squamous lining replaced by metaplastic columnar epithelium visible macroscopically" o Malignant risk
Specialised intestinal metaplasia (0.4-0.6% per year- low risk)
Low grade dysplasia (0.8-1.6% per year)
High grade dysplasia (6-12% per year- High risk and treat using endoscopy)
Invasive adenocarcinoma o Treatment
Control symptoms & reduce complications (meds or surgery- don't know if stops cancer progression)
Proton pump inhibitors or anti-reflux surgery
Endoscopic dilatation if stricture
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