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Hepatitis A E Viruses Notes

Medicine Notes > Gastrointestinal (GI) System Notes

This is an extract of our Hepatitis A E Viruses document, which we sell as part of our Gastrointestinal (GI) System Notes collection written by the top tier of Bristol University students.

The following is a more accessble plain text extract of the PDF sample above, taken from our Gastrointestinal (GI) System Notes. Due to the challenges of extracting text from PDFs, it will have odd formatting:

Lecture 12 Hepatitis A-E Viruses

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Types of hepatitis

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Hepatitis A o Clinical features
? Incubation period: Average 30 days
? Jaundice by age group: <6 yrs= <10%; 6-14 yrs= 40-50%; >14 yrs=70-80%
? Complications: Fulminant hepatitis; Cholestatic hepatitis; Relapsing hepatitis
? Chronic Sequelae= NONE o Virus transmission
? Close personal contact
? Contaminated food, water
? Blood exposure (rare) o Lab diagnosis
? Acute infection diagnosed by detection of HAV-IgM in serum EIA
? Past infection i.e. immunity determined by detection of HAV-IgG by EIA o Prevention- Immune Globulin
? Pre-exposure (travellers)
? Post-exposure (within 14 days)

* Routine (household and other intimate contacts)

* Selected situations (institutions, common source exposure) Hepatitis B o Clinical features
? Incubation period: Average 60-90 days
? Jaundice: <5yrs= <10%; >5yrs=30-50%
? Acute-case fatality rate= 0.5-1%
? Chronic infection: depends upon age of infection (older=less likely)
? Premature mortality from chronic liver disease= 15-25%
o Spectrum of chronic hep. B
? Chronic persistent hep. (asymptomatic)
? Chronic active hep (symptomatic exacerbations of hep.)
? Cirrhosis of liver

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