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Mitosis Notes

Medicine Notes > Organisation of the Body Notes

This is an extract of our Mitosis document, which we sell as part of our Organisation of the Body Notes collection written by the top tier of Oxford students.

The following is a more accessble plain text extract of the PDF sample above, taken from our Organisation of the Body Notes. Due to the challenges of extracting text from PDFs, it will have odd formatting:

-Cells undergo cell division- to replace cells that have been lost due to maturation/apoptosis
-cells also divide- inresponse to an increased work load
-seen by light microscope- labelled radioactive DNA precursors such as H3 Thymidine- recorded using autoradiographic methods G0 phase
-most of the cells in this phase are differentiated- specific function
-to leave this phase requires growth factors Progression through the cell cycle is dependent by cyclin dependent kinase which phosphorylates other substrates and promote cell divison G1
-longest and most variable cell cycle phase- determines the length of the whole cycle
-requires continuous signals from growth factors
-large amount of growth- large amounts of RNA and protein synthesis
-restriction point at the end of G1 phase- determines whether cell can enter S phase- cell size, condition of the chromosomes, external environment or enter the G0 phase
-p53 stimulates the G1 phase to progress onto S phase S
-all replication needed to create two cell occurs- DNA and organelles
-synthesis of DNA, replication of centrosomes
-centrosomes are key for cell division - each consists of two centiroles- barrels of 9 triplet microtubules G2
-phase of chromosome packaging
-synthesis of proteins required for mitosis

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