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Connective Tissue Notes

Medicine Notes > Organisation of the Body Notes

This is an extract of our Connective Tissue document, which we sell as part of our Organisation of the Body Notes collection written by the top tier of Oxford students.

The following is a more accessble plain text extract of the PDF sample above, taken from our Organisation of the Body Notes. Due to the challenges of extracting text from PDFs, it will have odd formatting:

Connective tissue Definition: association of the extracellular matrix and the various cell types within it. It varies in type and amount in different locations of the body. Functions: Mechanical
-supporting matrix for highly organised structures such as the blood, nerve, lymp
-force transmitter- tendon-MUSCLE to bone, ligaments- bone to bone
-facilitates movement between structures Metabolic
-route for exchange between metabolites and regulatory molecules- between the blood and tissues between blood and tissues
-storage of fat- subcutaneous and mesentries Defense
-fat in the superficial fascia forms an insulating layer. Fat in the loculi of loose connective tissue of the dermis provides cushioning and padding
-Inflammation- macrophages and mast cells of the connective tissue- inflammationlocal response to bacteria Repair- after injury fibroblasts lay down collagen fibres- scar tissue STRUCTURE
-cells Fibroblasts-STRUCTURAL ROLE: embryonic mesenchyme- secrete most of the extracellular matrix components (fibres and ground substancs)
-GAG, PROTEOGLYCANS, COLLAGEN, ELASTIC, GLYCOPROTEINS , GROWTH FACTORS
-Secrete fibroblast growth factors- mutation in FGF3R leads to Achondroplasia
-plays a role in wound healing
-active and quiescent forms are distinct-active fibroblasts have euchromatin and a prominent nucleolus and ovid shaped nuclei
-queicsent fibroblasts have fusiform cells, less ERcytoplasm is elongated into a thin line
-Secretes glycogen in a particular orientation Macrophages: DEFENCE-phagocytosis, antigen presentation, cytokine secretion
- resident phagocytic cells- blood monocytes-engulf and remove invading organisms and dead cells- secrete cytokines the local inflammatory response - recruit other phagocytic cells such as leucocytes from the blood stream
-specialised roles in certain tissues: Kuppfer cells (liver), microgilia (CNS), Langerhan's cells (epidermis),osteoclasts in bone

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