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Genes In Population 5b Notes

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This is an extract of our Genes In Population 5b document, which we sell as part of our Biochemistry Notes collection written by the top tier of Oxford students.

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Genes in population Hardy-Weinberg principle: relative proportions of different gentoypes and phenotypes remain constant from one generation to another
-The assumption is that there are only 2 alleles for a particular gene in the population
-The gene pool= total alleles in the population (2 x population number)
-p= probability of a dominant allele, q= probability of a recessive allele so p+q=1
-p2 = probability of Homozygous for the dominant Allele
-q2 = probability of Homozygous for the recessive allele
-2pq= probability for being heterozygous
- p2 + 2pq + q2 = 1
-Use: allows us to predict the incidence of diseased individuals and unaffected carriers is p and q are known
-In order to calculate frequency of carriers you must do 2 x p x q not just p x q

-This theory is true for the ideal population
-Random mating -selection of a partner regardless of the partner's genotype
-no new mutations
-no selection for or against any particular genotype
-This is seen for neutral genes such as blood groups, enzyme variants

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