This is a sample of our (approximately) 3 page long Lipoproteins notes, which we sell as part of the Biochemistry Notes collection, a First package written at Oxford in 2014 that contains (approximately) 216 pages of notes across 33 different documents.
The original file is a 'Word (Docx)' whilst this sample is a 'PDF' representation of said file. This means that the formatting here may have errors. The original document you'll receive on purchase should have more polished formatting.
The following is a plain text extract of the PDF sample above, taken from our Biochemistry Notes. This text version has had its formatting removed so pay attention to its contents alone rather than its presentation. The version you download will have its original formatting intact and so will be much prettier to look at.
Lipoprotein metabolism and lipid disorders Functions of lipids
-Energy: Triacylglycerides, fatty acids-very reduced so large amounts of energy are released per gram. Disadv: very hydrophobic, problematic for transport-Slow
-Structural: Phospholipids, cholesterol, sphingolipids
-Signalling: Prostoglandins, ionsitol lipids, steroid hormones, sphingolipids
-Involvement in inflammatory responses Lipids in plasma Lipids carried by lipoproteins
-Triacylglycerol: non polar
-Esterified cholesterol: Non polar
-Unesterified cholesterol: relatively polar/ampihatic Albumin: Non esterified free fatty acids, ampiphatic, concentrations of free fatty acids (non esterified must remain very low due to their detergent like properties of dissolving membranes) Lipoprotein particle Core: material transported- Triacylglycerol, cholesterol ester - both very hydrophobic molecules, also fat soluable vitamins A,D,E,K, fat soluable toxins Surface shell/monolayer: Unesterified cholesterol, monolayer of phospholipidsampiphatic molecules that can react with both the hydrophobic and hydrophilic environments
-There are also apolipoproteins. Apolipoprotein B has a structural role, only one copy present and is a very large protein. Apolipoprotein E is a ligand for the tissues that express lipoprotein receptors. Apolipoprotein C2 is a coenzyme for lipase enzyme Lipoprotein lipase
-Lipoprotein lipase is found attached to the endothelial cells of capillaries by a heparan sulphate proteoglycans anchor and cleaves the triglyceride from the lipoprotein-chylomicrons/Very low density lipoproteins
-Requires apolipoprotein C2 as a coactivator which is found on chylomicrons/VLDL
-This allows the triglycerides to enter tissues such as the heart/adipose tissue
****************************End Of Sample*****************************
Buy the full version of these notes or essay plans and more in our Biochemistry Notes.